The clinical stages of squamous cell carcinoma in head and neck is one of the most important prognostic parameters. But prognostic indicators to identify the proliferative activities of cancer cell are necessary because even in the same clinical
stages.
prognosis is different.
PCNA indicates the proliferative activity of cells in the late G1 and S phase and also it is one of prognosticators which mean the malignant potency in cancer cells.
This study evaluated the positive PCNA ratio by means of immunohistochemical staining for monoclonal antibody to PCNA in 38 squamous cell earcinomas of head and neck from 1984 to 1988.
@ES The results were as follows:
@EN 1. Average PCNA ratio was 49.1±13.62%.
2. PCNA ratio according to histopathologic differentiation was 34.6±6.32% in grade 1, 60.3±10.74% in grade 2, and 68.1±12.10% in grade 3. The poor histopathologic differentiation was related to high PCNA ratio(p<0.05).
3. PCNA ratio was not related to primary sites and clinical staging system. PCNA ratio was 46.6±72.6% in the cases without cervical lymph node metastsis and 51.7±10.14% in the cases with regional metastasis. PCNA ratio was not related to the
extracapsular spread of neoplastic cells in metastatic lymph node.
4. PCNA ratio was 48.0±9.20 in the cases with 3 year disease free survival, and 50.7±12.31% in decreased or regional recurrent cases. Therefore, there was no significant difference, but PCNA ratio was higher in cases of distant metastsis than
abscence
of distant metastsis(p>0.05).
In conclusion, PCNA ratio was correlated to histopathologic differentiation but not closely correlated to clinical parameters. So PCNA ratio itself was not a single indicator to predict the prognosis, but the high PCNA ratio showed a tendency to
increase distant metastasis.
|